If your first time to use ledger - https://www.ledger.com/start

As of Aug 2021 -
Notes - make sure to turn on DEVELOPER mode in settings in order to install the Handshake app in Ledger.
https://gist.github.com/pinheadmz/500df1a882399fd5c41543739c95d13e

Main guide from Bob Wallet
https://github.com/kyokan/bob-wallet/wiki/Ledger

Matt Zipkins video